PEP side effects, and how to handle them.

Modern PEP is much easier to take than it used to be. Most people have mild side effects or none at all, and they usually settle in the first week or two.

  • Most peopleMild or none
  • Usually settle1 to 2 weeks
  • SupportWhole course
A Hollis nurse holding a tablet and a pharmacy bag

Common side effects

  • Nausea or an upset stomach
  • Tiredness
  • Headache
  • Loose stools
  • Trouble sleeping or vivid dreams

These are usually mild and short-lived. Taking the dose with food, at the same time each day, often helps. Your physician can suggest simple remedies and, if needed, prescribe something for nausea.

Rare but important

Call your physician straight away if you notice yellowing of the skin or eyes, a spreading rash, severe abdominal pain, or feel very unwell. These are uncommon, but they need prompt review.

Do not stop early

PEP works best when you take the full 28 days without missing doses. If you miss one, take it as soon as you remember and tell your physician. If side effects are making it hard, speak to your physician before stopping. There is almost always a way to make it easier, including switching one of the medicines.

How we support you

Every Hollis course is managed by one physician, with check-ins during the 28 days. PEP Complete adds a side-effect comfort kit, weekly check-ins and a direct WhatsApp line to your physician.

This guide is general information, not a diagnosis. Every situation is different, so speak to a physician about yours. If you are in immediate danger, call 999.

Questions

Common questions.

Still unsure? The physician on duty can talk it through with you, any hour.

Can I drink alcohol on PEP?

Moderate alcohol does not stop PEP working, but heavy drinking makes missed doses more likely and can worsen side effects. Ask your physician about your situation.

Can I work and exercise on PEP?

Yes. Most people carry on as normal.

Do other medicines interact with PEP?

Some do, including certain antacids, supplements and other prescriptions. Tell your physician everything you take.